There are many different options out there.
This post does a good job describing several options: http://stackoverflow.com/questions/12232784/how-to-develop-desktop-apps-using-html-css-javascript
Multi-platform options (top 3 are probably the best options):
Windows-specific examples:
For animation support, you'll want an option that runs/includes a newer browser (like Chrome).
The easiest thing to do might be to build an AIR app from Dreamweaver: http://www.adobe.com/products/air.html